CCR1 polyclonal, anti-human, mouse, primate antibody

Background:
Chemokines play an important role in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

Other Names:
CMKBR1 , CMKR1 , CD191 , CKR-1 , HM145 , MIP1aR , C-C chemokine receptor type 1

Primary Accession: P32246

Gene Name: CCR1

Gene ID: 1230

Concentration (mg/ml): 0.5 mg/ml