CCR5 Polyclonal Antibody

Background:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.

Research Area: Cancer, Cardiovascular, Immunology, Microbiology, Neuroscience, Signal Transduction

Synonyms:
AM4 7, C C chemokine receptor type 5, C C CKR 5, C-C chemokine receptor type 5, C-C CKR-5, C-C motif chemokine receptor 5 A159A, CC Chemokine Receptor 5, CC Chemokine Receptor Type 5, CC CKR 5, CC-CKR-5, CCCKR 5, CCCKR5, CCR 5, CCR-5, CCR5, CCR5 chemokine (C C motif) receptor 5, CCR5, CD 195, CD195, CD195 Antigen, Chemokine C C motif receptor 5, Chemokine receptor CCR5, CHEMR13, CKR 5, CKR5, CMKBR 5, CMKBR5, FLJ78003, HIV 1 Fusion Coreceptor, HIV-1 fusion coreceptor, HIV1 fusion coreceptor, IDDM22, MIP-1 alpha receptor

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse CCR5

Swissprot: P51682,O08556

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.55 mg/mL
Dilution: IHC 1:200-1:800

Storage:
Store at -20°C. Avoid freeze / thaw cycles.