CD10 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase(NEP), Neprilysin, or common acute lymphoblastic leukemia antigen(CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

Description:
Rabbit IgG polyclonal antibody for Neprilysin (MME) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Atriopeptidase antibody, CALLA antibody, CD10 antibody, CD10 antigen antibody, Common acute lymphocytic leukemia antigen antibody, DKFZp686O16152 antibody, EC 3.4.24.11 antibody, Enkephalinase antibody, EPN antibody, gp100 antibody, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody, Membrane metallo endopeptidase antibody, Membrane metallo endopeptidase variant 1 antibody, Membrane metallo endopeptidase variant 2 antibody, Membrane metalloendopeptidase antibody, Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody, Membrane metalloendopeptidase variant 1 antibody, Membrane metalloendopeptidase variant 2 antibody, MGC126681 antibody, MGC126707 antibody, MME antibody, NEP antibody, NEP_HUMAN antibody, Neprilysin antibody, Neutral endopeptidase 24.11 antibody, Neutral endopeptidase antibody, SFE antibody, Skin fibroblast elastase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CD10 recombinant protein (Position: Y52-W750). Human CD10 shares 94% amino acid (aa) sequences identity with both mouse and rat CD10.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.