CD10 Rabbit pAb

Background:
CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.

Cellular localization: Cell membrane

Specificity: Human

Alternative Names:
CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody

Immunogen: Recombinant Protein

Isotype: Rabbit Polyclonal IgG

Concentration: 1mg/ml

Recommended dilutions:  IHC 1:200-500

Observed band: 85kDa

GeneID: 4311

Swiss-Prot No.: P08473

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

NOTE: For Research Use Only