CD103 (Integrin alpha E) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ITGAE(INTEGRIN, ALPHA-E), also known as CD103, is an integrin protein that in human is encoded by the ITGAE gene. The ITGAE gene is mapped to chromosome 17p13 by inclusion within a BAC contig. ITGAE is expressed widely on intraepithelial lymphocyte(IEL) T cells(both alphabeta T cells and gammadelta T cells) and on some peripheral regulatory T cells(Tregs) which is important for decreasing the immune response and appears to play a crucial role in the prevention of autoimmune diseases. ITGAE shares overall homology with other alpha integrins but has a unique 55-amino acid "extra" region located just N-terminal to the I domain that contains 18 consecutive charged residues and a proteolytic cleavage site.

Description:
Rabbit IgG polyclonal antibody for Integrin alpha-E (ITGAE) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
A530055J10 antibody, alpha-E1 antibody, alpha-M290 antibody, aM290 antibody, Antigen CD103 antibody, CD 103 antibody, CD103 antibody, CD103 antigen antibody, HML 1 antigen antibody, HML-1 antigen antibody, HML1 antigen antibody, Human mucosal lymphocyte antigen 1 antibody, Human mucosal lymphocyte antigen 1, alpha subunit antibody, Huminae antibody, Integrin alpha E heavy chain antibody, Integrin alpha E light chain antibody, Integrin alpha E, epithelial-associated antibody, Integrin alpha E1 antibody, Integrin alpha IEL antibody, Integrin alpha M290 antibody, Integrin alpha-E heavy chain antibody, Integrin alpha-IEL antibody, Integrin, alpha E(antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) antibody, Integrin, alpha E antibody, ITAE_HUMAN antibody, Itgae antibody, MGC141996 antibody, MGC183601 antibody, Mucosal lymphocyte 1 antigen antibody, Mucosal lymphocyte antigen 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha E(1153-1168aa KRKYQQLNLESIRKAQ), different from the related rat and mouse sequences by two amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha E(1153-1168aa KRKYQQLNLESIRKAQ), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.