CD105/Endoglin(Center E395) polyclonal, anti-human antibody
€275.00
In stock
SKU
AC-ABV11336-100
Catalog Number: AC-ABV11336-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, FC
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, FC
Datasheet
Request Information
Background:
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
Other Names:
ENG, END, Endoglin
Primary Accession: P17813
Gene Name: ENG
Gene ID: 2022
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
Other Names:
ENG, END, Endoglin
Primary Accession: P17813
Gene Name: ENG
Gene ID: 2022
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