CD106 (VCAM-1) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CD106(cluster of differentiation 106) also known as vascular cell adhesion molecule 1(VCAM-1),is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. Cybulsky et al.(1991) mapped the VCAM1 gene to chromosome 1 by Southern analysis of somatic cell hybrids. Kumar et al.(1994) mapped the murine Vcam1 gene to chromosome 3 near Amy1.VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes,monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated.

Description:
Rabbit IgG polyclonal antibody for Vascular cell adhesion protein 1 (VCAM1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
CD106 antibody, CD106 antibody, CD106 Antigen antibody, DKFZp779G2333 antibody, INCAM 100 antibody, INCAM-100 antibody, L1CAM antibody, MGC99561 antibody, V-CAM 1 antibody, Vascular Cell Adhesion Molecule 1 antibody, Vascular cell adhesion protein 1 antibody, VCAM 1 antibody, VCAM-1 antibody, VCAM1 antibody, VCAM1_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse VCAM1(653-671aa YTIRQAQLQDAGIYECESK), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.