CD114 (GCSF Receptor) polyclonal, anti-human

Quantity: 100 µg

Background:
CSF3R(Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor(G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

Description:
Rabbit IgG polyclonal antibody for Granulocyte colony-stimulating factor receptor (CSF3R) detection. Tested with WB in Human.

Synonyms:
CD 114 antibody, CD114 antibody, CD114 antigen antibody, Colony stimulating factor 3 receptor(granulocyte) antibody, Colony stimulating factor 3 receptor antibody, CSF 3R antibody, CSF3R antibody, CSF3R_HUMAN antibody, Csfgr antibody, G CSF R antibody, G-CSF receptor antibody, G-CSF-R antibody, GCSFR antibody, Granulocyte colony stimulating factor receptor antibody, Granulocyte colony stimulating factor receptor precursor antibody, Granulocyte colony-stimulating factor receptor antibody, OTTHUMP00000009703 antibody, OTTHUMP00000009704 antibody, OTTHUMP00000009705 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor(254-271aa EPWQPGLHINQKCELRHK).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.