CD11a polyclonal, anti-human

Quantity: 100 µg

Background:
CD11a, also known as ITGAL or LFA-1, is a human gene which functions in the immune system. It is mapped to 16p11.2. CD11a is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. CD11a encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. It is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Description:
Rabbit IgG polyclonal antibody for Integrin alpha-L (ITGAL) detection. Tested with WB in Human.

Synonyms:
Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody, Antigen CD11A antibody, CD 11a antibody, CD11 antigen-like family member A antibody, CD11a antibody, CD11a antigen antibody, Integrin Alpha L antibody, Integrin alpha-L antibody, Integrin gene promoter antibody, Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) antibody, ITAL_HUMAN antibody, ITGAL antibody, ITGAL protein antibody, Leukocyte adhesion glycoprotein LFA 1 alpha chain antibody, Leukocyte adhesion glycoprotein LFA-1 alpha chain antibody, Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibody, Leukocyte function associated molecule 1 alpha chain antibody, Leukocyte function-associated molecule 1 alpha chain antibody, LFA 1 alpha antibody, LFA 1 antibody, LFA 1A antibody, LFA-1A antibody, LFA1A antibody, Ly15 antibody, Ly21 antibody, Lymphocyte function associated antigen 1 antibody, Lymphocyte Function Associated Antigen Type 1 alpha antibody, p180 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CD11a recombinant protein (Position: Q148-E523). Human CD11a shares 77% mino acid (aa) sequence identity with mouse CD11a.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.