CD11b (C3) (clone Bear-1), anti-human
€564.00
In stock
SKU
ARP-21-5034
Catalog Number: 21-5034
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (alphaMbeta2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of alphaMbeta2 is the common integrin beta2 subunit known as CD18, and integrin alphaMbeta2 thus belongs to the beta2 subfamily (or leukocyte) integrins. alphaMbeta2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migRation and has been impliCated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b).
Clone: Bear-1
Isotype: Mouse IgG1
Source: Bear-1 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with with purified Human monocytes.
Reactivity: human
Specificity: Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18. Bear-1 precipitated a 165-95-kDa complex and is found to be similar to Mo-1 (monocyte differentiation antigen).
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunoprecipitation
Storage: Store at 4C, or in small aliquots at -20C.
Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (alphaMbeta2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of alphaMbeta2 is the common integrin beta2 subunit known as CD18, and integrin alphaMbeta2 thus belongs to the beta2 subfamily (or leukocyte) integrins. alphaMbeta2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migRation and has been impliCated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b).
Clone: Bear-1
Isotype: Mouse IgG1
Source: Bear-1 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with with purified Human monocytes.
Reactivity: human
Specificity: Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18. Bear-1 precipitated a 165-95-kDa complex and is found to be similar to Mo-1 (monocyte differentiation antigen).
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunoprecipitation
Storage: Store at 4C, or in small aliquots at -20C.
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