CD11b polyclonal, anti-human, mouse, rat

Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens, Transporters

Pathway and Disease: Signaling Molecules and Interaction, Immune System, Infectious Diseases

Description:
CD11b is involved in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD11b is identical with CR-3, the receptor for the iC3b fragment of the third complement component. Genetic variations in CD11b have been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). SLEB6 is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

Alternate Names: CD11b, Integrin alpha-M, Leukocyte adhesion receptor MO1, Cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, Neutrophil adherence receptor, CD11 antigen-like family member B, CD11b antigen, ITGAM, CR3A

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P11215

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD11b.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Pirih F et al. 2011. J Bone Miner Res. 27(2): 309-318. PMID 21987408