CD11b polyclonal, anti-mouse

Quantity: 100 µg

Background:
ITGAM(Integrin Alpha-M), also called CD11B or Mo1 ALPHA SUBUNIT(MO1A), is one protein subunit that forms the heterodimeric integrin alpha-M beta-2(alphaMbeta2) molecule. A major surface antigen family on human leukocytes includes complement receptor type 3(CR3A; also called ITGAM, Mac1, or Mo1), lymphocyte function-associated(LFA) antigen type 1(ITGAL), and p150, 95(ITGAX). By in situ hybridization, Corbi et al.(1988) demonstrated that the genes encoding the alpha subunits of LFA1(ITGAL), Mac1, and p150, 95(ITGAX), all of which are involved in leukocyte adhesion, constitute a cluster on 16p13.1-p11. Callen et al.(1991) narrowed the assignment to 16p11.2. Inflammation plays an essential role in the initiation and progression of atherosclerosis. Simon et al.(2000) presented evidence that it also has a role in vascular repair after mechanical arterial injury(i.e., percutaneous transluminal coronary angioplasty, or PTCA).

Description:
Rabbit IgG polyclonal antibody for Integrin alpha-M (ITGAM) detection. Tested with WB in Mouse.

Synonyms:
Antigen CD11b p170 antibody, CD11 antigen like family member B antibody, CD11 antigen-like family member B antibody, CD11b antibody, CD11b antigen antibody, CD11b/CD18 antibody, CD49d antibody, Cell surface glycoprotein MAC 1 alpha subunit antibody, Cell surface glycoprotein MAC-1 subunit alpha antibody, Cell Surface Glycoprotein MAC1 Alpha Subunit antibody, Complement component 3 receptor 3 subunit antibody, Complement Component Receptor 3 Alpha antibody, Complement receptor type 3, alpha subunit antibody, CR 3 alpha chain antibody, CR-3 alpha chain antibody, CR3 Alpha Chain antibody, CR3 antibody, CR3A antibody, F730045J24Rik antibody, Integrin Alpha M antibody, Integrin alpha M chain antibody, Integrin alpha M complement component 3 receptor 3 subunit antibody, Integrin alpha-M antibody, Integrin beta 2 alpha subunit antibody, ITAM_HUMAN antibody, ITGAM antibody, Leukocyte Adhesion Receptor MO1 antibody, Ly-40 antibody, MAC 1 antibody, Mac-1a antibody, MAC1 antibody, Mac1, alpha subunit antibody, MAC1A antibody, Macrophage antigen alpha polypeptide antibody, MGC117044 antibody, Mo1, alpha subunit antibody, MO1A antibody, Neutrophil adherence receptor alpha M subunit antibody, Neutrophil Adherence Receptor antibody, SLEB6 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse CD11b(1135-1153aa KRQYKDMMNEAAPQDAPPQ).A synthetic peptide corresponding to a sequence at the C-terminus of mouse CD11b(1135-1153aa KRQYKDMMNEAAPQDAPPQ).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.