CD11B Polyclonal Antibody

Background:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Neuroscience, Signal Transduction, Stem Cells, Tags and Cell Markers

Synonyms:
CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, ITGAM, CD11b/ITAM

Immunogen: Recombinant fusion protein of human CD11B (NP_001139280.1).

Swissprot: P11215
Gene ID: 3684

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.