CD120a TNF-R1 polyclonal, anti-human

Protein Family: Receptors and Channels, Cellular Antigens

Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Cell Growth and Death, Endocrine System, Development and Behavior, Neurodegenerative Disorders, Infectious Diseases

Description:
Tumor necrosis factor receptor superfamily member 1A (CD120a TNF-R1) is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD120a TNF-R1contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.

Alternate Names: Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p60, p55, CD120a, TNFRSF1A, TNFAR, TNFR1

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000; IHC: 1:100-1:500

Accession No.: P19438

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD120a TNF-R1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1%BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.