CD120a (TNF Receptor I, TNFRSF1A) polyclonal, anti-human

Quantity: 100 µg

Background:
Tumor necrosis factor receptor 1(TNFR1), a potent cytokine, elicits a broad spectrum of biologic responses which are mediated by binding to a cell surface receptor. Its gene is located on 12p13.2. The coding region and the 3-prime untranslated region of TNFR1 are distributed over 10 exons. There are 2 different proteins that serve as major receptors for TNF-alpha, one associated with myeloid cells and one associated with epithelial cells. Additionally, TNFR1 associates with the MADD protein through a death domain-death domain interaction. MADD provides a physical link between TNFR1 and the induction of mitogen-activated protein(MAP) kinase(e.g., ERK2) activation and arachidonic acid release. TNFR1-induced apoptosis involves 2 sequential signaling complexes. Complex I, the initial plasma membrane-bound complex, consists of TNFR1, the adaptor TRADD, the kinase RIP1, and TRAF2 and rapidly signals activation of NF-kappa-B. In a second step, TRADD and RIP1 associate with FADD and caspase-8, forming a cytoplasmic complex, complex II.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) detection. Tested with WB, IHC-P in Human.

Synonyms:
CD120a antibody, FPF antibody, MGC19588 antibody, p55 antibody, p55 R antibody, P55R antibody, p60 antibody, TBP 1 antibody, TBP1 antibody, TBPI antibody, TNF R antibody, TNF R I antibody, TNF R55 antibody, TNF-R1 antibody, TNF-RI antibody, TNFAR antibody, TNFR 55 antibody, TNFR 60 antibody, TNFR antibody, TNFR-I antibody, TNFR1 antibody, TNFR55 antibody, TNFR60 antibody, TNFRI antibody, TNFRSF1A antibody, TNR1A_HUMAN antibody, Tumor necrosis factor alpha receptor antibody, Tumor necrosis factor binding protein 1 antibody, Tumor necrosis factor receptor 1 antibody, Tumor necrosis factor receptor superfamily member 1A antibody, Tumor necrosis factor receptor type 1 antibody, Tumor necrosis factor receptor type I antibody, Tumor necrosis factor-binding protein 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human TNF Receptor I(195-211aa CLPQIENVKGTEDSGTT) .

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.