CD120b (TNF Receptor II) polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) detection. Tested with WB, IHC-P in Mouse, Rat.

Synonyms:
CD 120b antibody, CD120b antibody, CD120b antigen antibody, Etanercept antibody, p75 antibody, p75TNFR antibody, p80 TNF alpha receptor antibody, p80 TNF-alpha receptor antibody, TBP-2 antibody, TBP2 antibody, TBPII antibody, TNF R II antibody, TNF R2 antibody, TNF R75 antibody, TNF-R2 antibody, TNF-RII antibody, TNFBR antibody, TNFR 2 antibody, TNFR-II antibody, TNFR2 antibody, TNFR75 antibody, TNFR80 antibody, TNFRII antibody, TNFRSF 1B antibody, TNFRSF1B antibody, TNR1B antibody, TNR1B_HUMAN antibody, Tumor necrosis factor beta receptor antibody, Tumor necrosis factor binding protein 2 antibody, Tumor necrosis factor receptor 2 antibody, Tumor necrosis factor receptor superfamily member 1B precursor antibody, Tumor necrosis factor receptor type II antibody, Tumor necrosis factor-binding protein 2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse TNF Receptor II (296-324aa QRDAKVPHVPDEKSQDAVGLEQQHLLTTA), different from the related human sequence by eleven amino acids, and from the related rat sequence by six amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of mouse TNF Receptor II (296-324aa QRDAKVPHVPDEKSQDAVGLEQQHLLTTA), different from the related human sequence by eleven amino acids, and from the related rat sequence by six amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.