CD124 (IL-4R) polyclonal, anti-human

Quantity: 100 µg

Background:
IL4R(INTERLEUKIN 4 RECEPTOR) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The IL4R gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E(IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain,a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor.The IL4R gene contains 12 exons and IL4R is a complex of at least 2 components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction. See also IL13RA1 and IL13RA2.

Description:
Rabbit IgG polyclonal antibody for Interleukin-4 receptor subunit alpha (IL4R) detection. Tested with WB, IHC-P in Human.

Synonyms:
582J2.1 antibody, CD124 antibody, IL 4R alpha antibody, IL-4 receptor subunit alpha antibody, IL-4-binding protein antibody, IL-4R subunit alpha antibody, IL-4R-alpha antibody, IL-4RA antibody, IL4-BP antibody, Il4r antibody, IL4R nirs variant 1 antibody, IL4RA antibody, IL4RA_HUMAN antibody, interleukin 4 receptor antibody, Interleukin 4 receptor alpha chain antibody, MGC118473 antibody, sIL4Ralpha/prot antibody, Soluble IL-4 receptor subunit alpha antibody, Soluble IL-4R-alpha antibody, Soluble interleukin-4 receptor subunit alpha antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human IL4R(219-232aa TKWHNSYREPFEQH).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.