CD137L (clone 41B446), anti-human

Decription:
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

Synonyms: 4-1BBL, TNFSF9

Clone: 41B446

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human CD137L.

Reactivity: human

Specificity: Recognizes human CD137L. Does not cross-react with mouse CD137L.

Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Applications:
Flow Cytometry: (1:1'000)
Western Blot: (1:2'000)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)