CD137L Polyclonal Antibody

Background:
tumor necrosis factor superfamily member 9(TNFSF9) Homo sapiens The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b

Alternative Names:
TNFSF9, Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL

Immunogen: The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 23

GeneID: TNFSF9

Storage: -20°C/1 year

NOTE: For Research Use Only