CD14 polyclonal, anti-human, mouse, rat

Protein Family: Transporters, Cellular Antigens

Pathway and Disease: Signaling Molecules and Interaction, Immune System, Infectious Diseases

Description:
Monocyte differentiation antigen CD14 (CD14) cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14 acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. CD14 up-regulates cell surface molecules, including adhesion molecules. CD14 is expressed strongly on the surface of monocytes and weakly on the surface of granulocytes.

Alternate Names: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14, urinary form, Monocyte differentiation antigen CD14, membrane-bound form

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P08571

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD14.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Singla D et al. 2015. PLoSONE. 10(3): e0120739. PMID 25768089.
[2] Ayman A et al. 2014. Am J Reprod Immunol. 71(3): 241-251. PMID# 24372928.
[3] Allam AB. et al. 2013. Am J Reprod Immunol. PMID 24372928.