CD14 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CD14 is a single-copy gene encoding 2 protein forms: a 50- to 55-kD glycosylphosphatidylinositol-anchored membrane protein (mCD14) and a monocyte or liver-derived soluble serum protein (sCD14) that lacks the anchor. This gene is located at bands 5q23-q31. The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns.

Description:
Rabbit IgG polyclonal antibody for Monocyte differentiation antigen CD14 (CD14) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
CD 14 antibody, CD_antigen=CD14 antibody, CD14 antibody, CD14 antibody, CD14 antigen antibody, CD14 molecule antibody, CD14_HUMAN antibody, LPS-R antibody, Mo2 antibody, Monocyte differentiation antigen CD14 antibody, Monocyte differentiation antigen CD14 urinary form antibody, Monocyte differentiation antigen CD14, membrane-bound form antibody, Myeloid cell specific leucine rich glycoprotein antibody, Myeloid cell-specific leucine-rich glycoprotein antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E. coli-derived human CD14 recombinant protein (Position: N65-D327). Human CD14 shares 69.8% and 66.8% amino acid (aa) sequence identity with mouse and rat CD14, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.