CD143 (ACE) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Angiotensin-converting enzyme (ACE), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system(RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, ACE was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.

Description:
Rabbit IgG polyclonal antibody for Angiotensin-converting enzyme (ACE) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
ACE 1 antibody, ACE antibody, ACE T antibody, ACE_HUMAN antibody, ACE1 antibody, Angiotensin converting enzyme somatic isoform antibody, Angiotensin converting enzyme testis specific isoform antibody, Angiotensin I converting enzyme antibody, Angiotensin I converting enzyme 1 antibody, Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody, Angiotensin-converting enzyme antibody, Carboxycathepsin antibody, CD 143 antibody, CD143 antibody, CD143 antigen antibody, DCP 1 antibody, DCP antibody, DCP1 antibody, Dipeptidyl carboxypeptidase 1 antibody, Dipeptidyl carboxypeptidase I antibody, Kininase II antibody, MGC26566 antibody, MVCD3 antibody, Peptidase P antibody, Peptidyl dipeptidase A antibody, soluble form antibody, Testicular ECA antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human ACE recombinant protein (Position: K651-Y864). Human ACE shares 73% and 76% amino acid (aa) sequences identity with mouse and rat ACE, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.