CD144 (VE-Cadherin) polyclonal, anti-human, mouse antibody
€340.00
In stock
SKU
AC-ABV11842-100
Catalog Number: AC-ABV11842-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Other Names:
Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144
Primary Accession: P33151
Gene Name: CDH5
Gene ID: 1003
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Other Names:
Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144
Primary Accession: P33151
Gene Name: CDH5
Gene ID: 1003
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