CD146 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CD146(cluster of differentiation 146) also known as the melanoma cell adhesion molecule(MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene. By radiation hybrid analysis, Kuske and Johnson(1999) mapped the CD146 gene to chromosome 11q23.3. It is a member of the immunoglobulin superfamily, is homologous to several cell adhesion molecules and is associated with tumor progression and the development of metastasis in human malignant melanoma. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. CD146 has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, and its expression may be linked to multipotency; mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface.

Description:
Rabbit IgG polyclonal antibody for Cell surface glycoprotein MUC18 (MCAM) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
A32 antigen antibody, CD 146 antibody, CD146 antibody, CD146 antigen antibody, Cell surface glycoprotein MUC18 antibody, Cell surface glycoprotein P1H12 antibody, Gicerin antibody, MCAM antibody, Melanoma adhesion molecule antibody, Melanoma associated antigen A32 antibody, Melanoma associated antigen MUC18 antibody, Melanoma associated glycoprotein MUC18 antibody, Melanoma cell adhesion molecule antibody, Melanoma-associated antigen A32 antibody, Melanoma-associated antigen MUC18 antibody, MelCAM antibody, MUC 18 antibody, MUC18 antibody, MUC18_HUMAN antibody, S endo 1 antibody, S endo 1 endothelial associated antigen antibody, S-endo 1 endothelial-associated antigen antibody, Sendo 1 endothelial associated antigen antibody, Sendo1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human CD146(584-600aa KKGKLPCRRSGKQEITL), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.