CD153 polyclonal, anti-human

Quantity: 100 µg

Background:
CD153 is a ligand for CD30. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 8 (TNFSF8) detection. Tested with IHC-P in Human.

Synonyms:
CD153 antibody, CD153 antigen antibody, CD30 antigen ligand antibody, CD30 L antibody, CD30 ligand antibody, CD30-L antibody, CD30L antibody, CD30LG antibody, MGC138144 antibody, TNFL8_HUMAN antibody, Tnfsf8 antibody, Tumor necrosis factor (ligand) superfamily member 8 antibody, Tumor necrosis factor ligand superfamily member 8 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CD153 recombinant protein (Position: Q63-D234). Human CD153 shares 75% amino acid (aa) sequence identity with mouse CD153.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.