CD156b (ADAM17) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ADAM17(ADAM metallopeptidase domain 17), also called TACE (tumor necrosis factor-alpha-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha(TNF-alpha) at the surface of the cell, and from within theintracellular membranes of the trans-Golgi network. This process, which is also known as "shedding", involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins(such as pro-TNF-alpha), and is of known physiological importance. ADAM17 was the first "sheddase" to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules,receptors, ligands, and enzymes.

Description:
Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
A disintegrin and metalloproteinase domain 17(tumor necrosis factor, alpha, converting enzyme) antibody, A disintegrin and metalloproteinase domain 17 antibody, ADA17_HUMAN antibody, ADAM 17 antibody, ADAM metallopeptidase domain 17 antibody, ADAM17 antibody, ADAM17 protein antibody, CD 156b antibody, CD156b antibody, CD156b antigen antibody, CSVP antibody, Disintegrin and metalloproteinase domain-containing protein 17 antibody, MGC71942 antibody, Snake venom like protease antibody, Snake venom-like protease antibody, TACE antibody, TNF alpha convertase antibody, TNF alpha converting enzyme antibody, TNF-alpha convertase antibody, TNF-alpha-converting enzyme antibody, Tumor Necrosis Factor Alpha Converting Enzyme antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM17(806-824aa AASFKLQRQNRVDSKETEC), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM17(806-824aa AASFKLQRQNRVDSKETEC), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.