CD156c Polyclonal Antibody

Background:
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).

Research Area: Cancer, Cell Biology, Signal Transduction

Synonyms:
A disintegrin and metalloprotease domain 10, A disintegrin and metalloproteinase domain 10, AD 10, AD10, AD18, ADA10, ADAM 10, ADAM metallopeptidase domain 10, ADAM10, CD 156c, CD156c, CD156c antigen, CDw156, disintegrin and metalloproteinase domain containing protein 10, Disintegrin and metalloproteinase domain-containing protein 10, HsT 18717, HsT18717, Kuz, Kuzbanian, Kuzbanian protein homolog, Kuzbanian, Drosophila, homolog of, MADM, Mammalian disintegrin metalloprotease, Mammalian disintegrin-metalloprotease, RAK

Immunogen: Recombinant protein of human ADAM10

Swissprot: O14672
Gene Accession: BC126253

Calculated MW: 84 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-16523/sc-31853/sc-31855/sc-16524/sc-25578