CD16 (Fc-gamma Receptor III) (clone HuNK2), anti-human
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In stock
SKU
ARP-24-2214-MSM3
Catalog Number: 24-2214-MSM3
Size: 100 µl, 0.5 ml, 1 ml
Isotype: Mouse IgG2a, kappa
Size: 100 µl, 0.5 ml, 1 ml
Isotype: Mouse IgG2a, kappa
Decription:
Recognizes a protein of 50-65kDa, identified as CD16 (Workshop IV; Code N39 ) (also known low affinity Fc receptor III for IgG (FcRIII) or Leu 11). CD16 exists as a polypepetide-anchored from (FCRIIIA or CD16A) on human natural killer (NK) cells and monocytes/ macrophages and as a glycosylphosphatidylinositol (GPI)-anchored form (FcRIIIB or CD16B) on neutrophils. CD16B is polymorphic and the two alleles are termed NA1 and NA2.3 CD16 plays a role in signal transduction, NK cell activation and antibody-dependent cellular cytotoxicity. This monoclonal antibody has been showed to inhibit the binding of immune complex to NK cells, inhibit cytotoxicity of NK cells, and induce calcium fluxes in NK cells and neutrophils.
Synonyms: FcRIIIa, FCR-10, FcRIII, FCGRIII, FcR-10, Fc fragment of IgG, low affinity IIIa, receptor for (CD16), neutrophil-specific antigen NA, CD16a, low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIIIa, immunoglobulin G Fc receptor III, Fc-gamma RIII-alpha, Fc-gamma receptor IIIb (CD16), CD16a antigen, Fc-gamma receptor III-2 (CD 16), FCGR3, Fc gamma receptor III-A, FCG3, low affinity III, receptor for (CD16), Fc-gamma RIII, IGFR3FcgammaRIIIA, CD16FCRIIIA, FCRIII, Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Clone: HuNK2
Isotype: Mouse IgG2a, kappa
Immunogen: Human peripheral blood lymphocytes from a NK-leukemia patient.
Reactivity: human. Others not-tested.
Form: Purified, in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applications: Functional Studies (Order Ab without BSA & Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Optimal dilution for a specific application should be determined.
Reactivity: K-562 or U-937 cells. Lymph nodes and tonsils.
Concentration: 0.2mg/ml
Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Recognizes a protein of 50-65kDa, identified as CD16 (Workshop IV; Code N39 ) (also known low affinity Fc receptor III for IgG (FcRIII) or Leu 11). CD16 exists as a polypepetide-anchored from (FCRIIIA or CD16A) on human natural killer (NK) cells and monocytes/ macrophages and as a glycosylphosphatidylinositol (GPI)-anchored form (FcRIIIB or CD16B) on neutrophils. CD16B is polymorphic and the two alleles are termed NA1 and NA2.3 CD16 plays a role in signal transduction, NK cell activation and antibody-dependent cellular cytotoxicity. This monoclonal antibody has been showed to inhibit the binding of immune complex to NK cells, inhibit cytotoxicity of NK cells, and induce calcium fluxes in NK cells and neutrophils.
Synonyms: FcRIIIa, FCR-10, FcRIII, FCGRIII, FcR-10, Fc fragment of IgG, low affinity IIIa, receptor for (CD16), neutrophil-specific antigen NA, CD16a, low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIIIa, immunoglobulin G Fc receptor III, Fc-gamma RIII-alpha, Fc-gamma receptor IIIb (CD16), CD16a antigen, Fc-gamma receptor III-2 (CD 16), FCGR3, Fc gamma receptor III-A, FCG3, low affinity III, receptor for (CD16), Fc-gamma RIII, IGFR3FcgammaRIIIA, CD16FCRIIIA, FCRIII, Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Clone: HuNK2
Isotype: Mouse IgG2a, kappa
Immunogen: Human peripheral blood lymphocytes from a NK-leukemia patient.
Reactivity: human. Others not-tested.
Form: Purified, in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applications: Functional Studies (Order Ab without BSA & Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Optimal dilution for a specific application should be determined.
Reactivity: K-562 or U-937 cells. Lymph nodes and tonsils.
Concentration: 0.2mg/ml
Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
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