CD167 (MCK10) polyclonal, anti-human, rat

Quantity: 100 µg

Background:
DDR1(Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al.(2000) showed that Ddr1 was highly expressed in the cerebellum of developing and adult mouse brain, and that both Ddr1 and collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of collagen I- and IV-expressing mouse pial cells with Ddr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.

Description:
Rabbit IgG polyclonal antibody for Epithelial discoidin domain-containing receptor 1 (DDR1) detection. Tested with WB in Human, Rat.

Synonyms:
CAK antibody, CD 167 antibody, CD167 antibody, CD167 antigen-like family member A antibody, CD167a antibody, Cell adhesion kinase antibody, DDR 1 antibody, DDR antibody, DDR1 antibody, DDR1_HUMAN antibody, Discoidin domain receptor antibody, Discoidin domain receptor tyrosine kinase 1 antibody, Discoidin receptor tyrosine kinase antibody, Discoidin receptor tyrosine kinase isoform a antibody, EDDR 1 antibody, EDDR1 antibody, Epithelial discoidin domain receptor 1 antibody, Epithelial discoidin domain-containing receptor 1 antibody, Epithelial specific receptor kinase antibody, HGK2 antibody, Mammarian carcinoma kinase 10 antibody, Mammary carcinoma kinase 10 antibody, MCK-10 antibody, MCK10 antibody, NEP antibody, Neuroepithelial tyrosine kinase antibody, Neurotrophic tyrosine kinase receptor type 4 antibody, NTRK 4 antibody, NTRK4 antibody, OTTHUMP00000029343 antibody, OTTHUMP00000029344 antibody, OTTHUMP00000029345 antibody, OTTHUMP00000029346 antibody, OTTHUMP00000029347 antibody, OTTHUMP00000164863 antibody, OTTHUMP00000164867 antibody, OTTHUMP00000222080 antibody, Protein-tyrosine kinase 3A antibody, Protein-tyrosine kinase RTK-6 antibody, PTK 3 antibody, PTK 3A protein tyrosine kinase 3A antibody, PTK3 antibody, PTK3A antibody, Receptor tyrosine kinase NEP antibody, RTK 6 antibody, RTK6 antibody, TRK E antibody, TRKE antibody, Tyrosine kinase DDR antibody, Tyrosine kinase receptor E antibody, Tyrosine-protein kinase CAK antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human MCK10(898-913aa FSQLHRFLAEDALNTV), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.