CD167a DDR1 polyclonal HRP, anti-human, mouse, rat

Protein Family: Cell Adhesion Molecules, Enzymes, Protein Kinases, Receptors and Channels

Pathway and Disease: Cancers, Cell Communication, Signal Transduction

Description:
DDR1 (Epithelial discoidin domain-containing receptor 1, CD167a) is a receptor tyrosine kinase involved in cell-cell interactions and recognition. It is expressed in epithelial cells especially in the kidney, lung, gastrointestinal tract, and brain, and more highly in human breast, ovarian, esophageal, and pediatric brain tumors. Types I-VI collagen all induce the autophosphorylation of DDR1. Collagen regulates the interaction of DDR1 with KIBRA (WWC1), activating MAPK; these events are involved in mammary gland development.

Alternate Names: Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, Tyrosine kinase DDR, Discoidin receptor tyrosine kinase, Tyrosine-protein kinase CAK, Cell adhesion kinase, TRK E, Protein-tyrosine kinase RTK 6, CD167a antigen, HGK2, DDR1, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q08345

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD167a.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA and 0.02% gentamicin. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Product is guaranteed 6 months from the date of shipment.