CD177 polyclonal, anti-human, mouse

Background:
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.

Synonyms: HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1

Cellular Location: Cell membrane GPI-anchor Lipid-anchor

Immunogen:
Recombinant protein of human CD177

Gene Symbol: CD177

Gene ID: 57126

Swiss prot: Q8N6Q3

Calculated MW: 46kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.