CD177 Polyclonal Antibody

Background:
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.

Research Area: Immunology

Synonyms:
CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, NB1GP

Immunogen: Recombinant fusion protein of human CD177 (NP_065139.2).

Swissprot: Q8N6Q3
Gene ID: 57126

Calculated MW: 15 kDa/27 kDa/46 kDa
Observed MW: 45 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.