CD178 (Fas Ligand) polyclonal, anti-human

Quantity: 100 µg

Background:
Fas ligand(FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor(TNF) family. Its binding with its receptor induces apoptosis. The human FASL gene consists of approximately 8 kb and is split into 4 exons. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Fas ligand or FasL is a homotrimeric type II transmembrane protein. It signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 6 (FASLG) detection. Tested with WB, IHC-P in Human.

Synonyms:
ALPS1B antibody, APO1L antibody, Apoptosis(APO 1) antigen ligand 1 antibody, Apoptosis antigen ligand 1 antibody, Apoptosis antigen ligand antibody, APT1LG1 antibody, APTL antibody, CD178 antibody, CD178 antigen antibody, CD95 ligand antibody, CD95-L antibody, CD95L antibody, CD95L protein antibody, FAS antigen ligand antibody, Fas L antibody, Fas ligand(TNF superfamily member 6) antibody, Fas ligand antibody, FASL antibody, Fasl Fas ligand(TNF superfamily member 6) antibody, FASLG antibody, Generalized lymphoproliferative disease antibody, Gld antibody, soluble form antibody, TNF superfamily member 6 antibody, TNFL6_HUMAN antibody, TNFSF6 antibody, Tumor necrosis factor(ligand) superfamily member 6 antibody, Tumor necrosis factor ligand superfamily member 6 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Fas Ligand(263-281aa ELSLVNFEESQTFFGLYKL).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.