CD178 (Fas Ligand) polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. It is mapped to 1q24.3. FASL may contribute to the immune privilege of tumors. Pharmacologic products that render infiltrating T cells insensitive to FASL-induced killing may break the immunologic unresponsiveness to melanoma and provide a complementary approach in the therapy of malignant melanoma. FASL-mediated apoptosis is important for skin homeostasis, the dysregulation of FAS-FASL interactions may be central to the development of skin cancer. Polymorphisms affecting either the expression or biologic activities of FAS or FASL may contribute to the genetic risk of developing T-cell lymphoblastic lymphomas.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 6 (FASLG) detection. Tested with WB, IHC-P in Mouse, Rat.

Synonyms:
ALPS1B antibody, APO1L antibody, Apoptosis (APO 1) antigen ligand 1 antibody, Apoptosis antigen ligand 1 antibody, Apoptosis antigen ligand antibody, APT1LG1 antibody, APTL antibody, CD178 antibody, CD178 antigen antibody, CD95 ligand antibody, CD95-L antibody, CD95L antibody, CD95L protein antibody, Fas antigen ligand antibody, Fas L antibody, Fas ligand (TNF superfamily member 6) antibody, Fas ligand antibody, FASL antibody, Fasl Fas ligand (TNF superfamily member 6) antibody, FASLG antibody, Generalized lymphoproliferative disease antibody, Gld antibody, soluble form antibody, TNF superfamily member 6 antibody, TNFL6_HUMAN antibody, TNFSF6 antibody, Tumor necrosis factor (ligand) superfamily member 6 antibody, Tumor necrosis factor ligand superfamily member 6 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived mouse Fas Ligand recombinant protein (Position: Q128-L279). Mouse Fas Ligand shares 82% and 93% amino acid (aa) sequences identity with human and rat, respectively.E.coli-derived mouse Fas Ligand recombinant protein (Position: Q128-L279). Mouse Fas Ligand shares 82% and 93% amino acid (aa) sequences identity with human and rat, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.