CD18 (clone HI18a) PE, anti-human
€435.00
In stock
SKU
251062
Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens
Pathway and Disease: Cell Motility, Immune System, Signaling Molecules and Interaction
Description:
The CD18 (HI18a) antibody recognizes a 95-kDa transmembrane protein, integrin beta-2 subunit, which associates respectively with the integrin α subunits: CD11a, CD11b, CD11c and CD11d forming four heterodimers named CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150,95) and CD11d/CD18 (αdβ2). CD18 integrin is expressed exclusively on leukocytes and plays an important role in homotypic and hetorotypic cellular adhesion in immune and inflammatory responses. Patients who have mutated CD18 gene do not express cell membrane CD11/CD18 integrins, a condition known as leucocyte adhesion deficiency (LAD).
Alternate Names: Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, MFI7
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody.
Accession No.: P05107
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Motility, Immune System, Signaling Molecules and Interaction
Description:
The CD18 (HI18a) antibody recognizes a 95-kDa transmembrane protein, integrin beta-2 subunit, which associates respectively with the integrin α subunits: CD11a, CD11b, CD11c and CD11d forming four heterodimers named CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150,95) and CD11d/CD18 (αdβ2). CD18 integrin is expressed exclusively on leukocytes and plays an important role in homotypic and hetorotypic cellular adhesion in immune and inflammatory responses. Patients who have mutated CD18 gene do not express cell membrane CD11/CD18 integrins, a condition known as leucocyte adhesion deficiency (LAD).
Alternate Names: Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, MFI7
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody.
Accession No.: P05107
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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