CD18 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ITGB2(INTEGRIN, BETA-2), also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. ITGB2 is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The ITGB2 gene is mapped to 21q22.3. The expression of CD18 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of ITGB2 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although ITGB2 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the "inside-out" signaling pathways.

Description:
Rabbit IgG polyclonal antibody for Integrin beta-2 (ITGB2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
95 subunit beta antibody, Beta 2(antigen CD18(p95) antibody, CD 18 antibody, CD18 antibody, CD18 antigen antibody, Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) antibody, Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta antibody, Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta antibody, Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit antibody, Cell surface adhesion glycoproteins LFA-1/CR3/p150 antibody, Complement component 3 receptor 3 and 4 subunit antibody, Complement receptor C3 beta subunit antibody, Complement receptor C3 subunit beta antibody, Integrin beta 2 antibody, Integrin beta chain beta 2 antibody, Integrin beta-2 antibody, Integrin, beta 2(complement component 3 receptor 3 and 4 subunit) antibody, ITB2_HUMAN antibody, ITGB 2 antibody, ITGB2 antibody, LAD antibody, LCAMB antibody, Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C antibody, Leukocyte Cell Adhesion Molecule CD18 antibody, LFA 1 antibody, LFA1 antibody, Lymphocyte function associated antigen 1 antibody, MAC 1 antibody, MAC1 antibody, Macrophage antigen 1(mac1) beta subunit antibody, MF17 antibody, MFI7 antibody, OTTHUMP00000115278 antibody, OTTHUMP00000115279 antibody, OTTHUMP00000115280 antibody, OTTHUMP00000115281 antibody, OTTHUMP00000115282 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human CD18(732-748aa LREYRRFEKEKLKSQWN), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human CD18(732-748aa LREYRRFEKEKLKSQWN), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.