CD183 (CXCR3) polyclonal, anti-human, rat

Quantity: 100 µg

Background:
Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes. It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes. CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG. CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.

Description:
Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 3 (CXCR3) detection. Tested with WB, IHC-P in Human, Rat.

Synonyms:
C-X-C chemokine receptor type 3 antibody, CD 183 antibody, CD182 antibody, CD183 antibody, Chemokine (C X C motif) receptor 3 antibody, Chemokine (C X C) receptor 3 antibody, Chemokine CXC Motif Receptor 3 antibody, CKR L2 antibody, CKR-L2 antibody, CKRL2 antibody, CMKAR3 antibody, CXC-R3 antibody, CXCR-3 antibody, CXCR3 antibody, CXCR3_HUMAN antibody, G Protein Coupled Receptor 9 antibody, G protein-coupled receptor 9 antibody, GPR9 antibody, Interferon-inducible protein 10 receptor antibody, IP-10 receptor antibody, IP10 antibody, IP10 R antibody, IP10 receptor antibody, IP10-R antibody, IP10R antibody, Mig R antibody, Mig receptor antibody, Mig-R antibody, MIGR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.E.coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.