CD183 (Rodent) polyclonal, anti-mouse, rat
€469.00
In stock
SKU
252284
Catalog Nr.: 252284
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
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Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: Cellular Antigens, Cytokines, Receptors and Channels
Pathway and Disease: Cell Growth and Death, Immune System, Signaling Molecules and Interaction
Description:
Chemokine receptor CXCR3 (CD183) is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Binding of CXCL9, CXCL10, and CXCL11 to CD183 is able to elicit increases in intracellular Ca2++ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK). CD183 binds to CCL21 and is expressed in lymphoid organs and Th1 cells. CXCR3 has been implicated in the following diseases, atherosclerosis, multiple sclerosis, pulmonary fibrosis, type 1 diabetes, autoimmune myasthenia gravis, nephrotoxic nephritis, acute cardiac allograft rejection, and possibly Celiac Disease.
Alternate Names: CXC-R3, CD183, C-X-C chemokine receptor type 3, CXCR-3, Interferon-inducible protein 10 receptor, IP-10 receptor, Cmkar3, CXCR3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: O88410
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse CD183.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Tsutahara K et al. 2012. Nephrology Dialysis Transplantaion. 27(10): 3799-3806. PMID#22904101
Pathway and Disease: Cell Growth and Death, Immune System, Signaling Molecules and Interaction
Description:
Chemokine receptor CXCR3 (CD183) is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Binding of CXCL9, CXCL10, and CXCL11 to CD183 is able to elicit increases in intracellular Ca2++ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK). CD183 binds to CCL21 and is expressed in lymphoid organs and Th1 cells. CXCR3 has been implicated in the following diseases, atherosclerosis, multiple sclerosis, pulmonary fibrosis, type 1 diabetes, autoimmune myasthenia gravis, nephrotoxic nephritis, acute cardiac allograft rejection, and possibly Celiac Disease.
Alternate Names: CXC-R3, CD183, C-X-C chemokine receptor type 3, CXCR-3, Interferon-inducible protein 10 receptor, IP-10 receptor, Cmkar3, CXCR3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: O88410
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse CD183.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Tsutahara K et al. 2012. Nephrology Dialysis Transplantaion. 27(10): 3799-3806. PMID#22904101
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