CD184 (CXCR4) polyclonal, anti-human

Quantity: 100 µg

Background:
CXCR4(Chemokine,CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. By PCR analysis of human/hamster hybrid cell DNA, Herzog et al.(1993) showed that the NPY3R gene is located on human chromosome 2. Feng et al.(1996) showed that transient expression of the CXCR4 gene allowed nonhuman cells coexpressing recombinant CD4 to undergo Env-CD4-mediated cell fusion and productive HIV-1 infection. Peled et al.(1999) demonstrated that SDF1 and its receptor CXCR4 are critical for murine bone marrow engraftment by human SCID repopulating stem cells. Treatment of human cells with anti-CXCR antibodies prevented engraftment.

Description:
Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4 (CXCR4) detection. Tested with WB in Human.

Synonyms:
C-X-C chemokine receptor type 4 antibody, CD184 antibody, CD184 antigen antibody, Chemokine(C X C motif) receptor 4 antibody, Chemokine CXC Motif Receptor 4 antibody, CXC-R4 antibody, CXCR-4 antibody, CXCR4 antibody, CXCR4_HUMAN antibody, D2S201E antibody, FB22 antibody, Fusin antibody, HM89 antibody, HSY3RR antibody, LAP 3 antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, Leukocyte derived seven transmembrane domain receptor antibody, Leukocyte-derived seven transmembrane domain receptor antibody, Lipopolysaccharide associated protein 3 antibody, Neuropeptide Y receptor Y3 antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3 antibody, NPYY3R antibody, Probable G protein coupled receptor lcr1 homolog antibody, SDF 1 receptor antibody, SDF-1 receptor antibody, SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody, Stromal cell derived factor 1 receptor antibody, Stromal cell-derived factor 1 receptor antibody, WHIM antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4(31-43aa EENANFNKIFLPT).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.