CD184 (CXCR4) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1, it functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. Tachibana et al.(1998) conclude that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization.

Description:
Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4 (CXCR4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
C-X-C chemokine receptor type 4 antibody, CD184 antibody, CD184 antigen antibody, Chemokine(C X C motif) receptor 4 antibody, Chemokine CXC Motif Receptor 4 antibody, CXC-R4 antibody, CXCR-4 antibody, CXCR4 antibody, CXCR4_HUMAN antibody, D2S201E antibody, FB22 antibody, Fusin antibody, HM89 antibody, HSY3RR antibody, LAP 3 antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, Leukocyte derived seven transmembrane domain receptor antibody, Leukocyte-derived seven transmembrane domain receptor antibody, Lipopolysaccharide associated protein 3 antibody, Neuropeptide Y receptor Y3 antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3 antibody, NPYY3R antibody, Probable G protein coupled receptor lcr1 homolog antibody, SDF 1 receptor antibody, SDF-1 receptor antibody, SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody, Stromal cell derived factor 1 receptor antibody, Stromal cell-derived factor 1 receptor antibody, WHIM antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4(18-33aa SGDYDSMKEPCFREEN), different from the related rat and mouse sequences by two amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4(18-33aa SGDYDSMKEPCFREEN), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.