CD1d polyclonal, anti-human

Quantity: 100 µg

Background:
CD1D(CD1d molecule) also known as R3G1, Antigen-presenting glycoprotein CD1d, R3G1, CD1D, is the sole group-2 member of the CD1 family of major histocompatibility(MHC)-like glycoproteins. Expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules. CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T(NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production. Jayawardena-Wolf et al. described 2 different pathways of Cd1d trafficking to endosomal compartments in mouse cells. A tyrosine-based motif governs recycling between the plasma membrane and the endosome, while Cd1d associates, like major histocompatibility complex class II antigens, with the invariant chain, or II, in the endoplasmic reticulum. Both pathways enhance antigen presentation to Cd1d-restricted natural killer T cells.

Description:
Rabbit IgG polyclonal antibody for Antigen-presenting glycoprotein CD1d (CD1D) detection. Tested with WB, IHC-P in Human.

Synonyms:
Antigen-presenting glycoprotein CD1d antibody, CD1.1 antibody, CD1A antibody, CD1d antibody, CD1D antigen antibody, CD1D antigen d polypeptide antibody, CD1d molecule antibody, CD1D_HUMAN antibody, Cd1d1 antibody, Differentiation antigen CD1 alpha 3 antibody, HMC class I antigen like glycoprotein CD1D antibody, Ly 38 antibody, MGC34622 antibody, R3 antibody, R3G1 antibody, T cell surface glycoprotein CD1d antibody, T cell surface glycoprotein CD1d precursor antibody, Thymocyte antigen CD1D antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CD1d(76-92aa FSDQQWETLQHIFRVYR).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.