CD201 rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013],function:Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.,PTM:A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.,PTM:N-glycosylated.,tissue specificity:Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.,

Synonyms: PROCR, EPCR, Endothelial protein C receptor, Activated protein C receptor, APC receptor, Endothelial cell protein C receptor, CD201

Gene Name: PROCR

Gene ID: 10544

SwissProt ID: Q9UNN8

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.