CD202b (TIE2) polyclonal, anti-human

Quantity: 100 µg

Background:
TIE2, also known as TEK tyrosine kinase, TIE2 gene is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

Description:
Rabbit IgG polyclonal antibody for Angiopoietin-1 receptor (TEK) detection. Tested with WB in Human.

Synonyms:
Angiopoietin 1 receptor antibody, Angiopoietin-1 receptor antibody, CD202b antibody, CD202b antigen antibody, CD202b antigen antibody, Endothelial tyrosine kinase antibody, Endothelium specific receptor tyrosine kinase 2 antibody, hTIE 2 antibody, hTIE 2 antibody, hTIE2 antibody, hTIE2 antibody, Hyk antibody, p140 TEK antibody, p140 TEK antibody, Soluble TIE2 variant 1 antibody, Soluble TIE2 variant 2 antibody, TEK antibody, tek tyrosine kinase antibody, TEK tyrosine kinase endothelial antibody, tek tyrosine kinase, endothelial antibody, TIE 2 antibody, TIE2_HUMAN antibody, Tunica interna endothelial cell kinase antibody, Tyrosine kinase with Ig and EGF homology domains 2 antibody, Tyrosine protein kinase receptor TEK antibody, Tyrosine protein kinase receptor TIE 2 antibody, Tyrosine protein kinase receptor TIE 2 antibody, Tyrosine-protein kinase receptor TEK antibody, Tyrosine-protein kinase receptor TIE-2 antibody, Venous malformations multiple cutaneous and mucosal antibody, VMCM 1 antibody, VMCM antibody, VMCM1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human TIE2 recombinant protein (Position: Q641-I830). Human TIE2 shares 91% amino acid (aa) sequence identity with mouse TIE2.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.