CD207 Polyclonal Antibody

Background:
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Research Area: Metabolism, Signaling transduction

Synonyms:
C type lectin domain family 4 member K, C-type lectin domain family 4 member K, CD 207, CD207, CD207 antigen, CD207 antigen, langerin, CD207 molecule, CLC4K, CLEC 4K, CLEC4K, Langerhans cell specific c type lectin, Langerin, RGD1565913

Immunogen: Recombinant human C-type lectin domain family 4 member K protein

Swissprot: Q9UJ71

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 2 mg/mL
Dilution: IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.