CD209 / DC-SIGN (clone C209/1781), anti-human
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In stock
SKU
AC-AH13293
Catalog Number: AC-AH13293
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: C209/1781
Applications: IHC-P, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: C209/1781
Applications: IHC-P, IF, FC
Datasheet
Request Information
Background:
DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
Other Names:
CD209; CDSIGN; CIRE; CLEC4L; DC-SIGN; DC-SIGN1; DCSIGN; Dendritic cell-specific ICAM-3 Grabbing Non-integrin 1; HIV GP120 Binding Protein; SIGN-R1; SIGNR5
Antigen Type:
Recombinant protein
Gene Name: CD209
Gene ID: 30835
Primary Accession: Q9NNX6
Other Accession: 278694
DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
Other Names:
CD209; CDSIGN; CIRE; CLEC4L; DC-SIGN; DC-SIGN1; DCSIGN; Dendritic cell-specific ICAM-3 Grabbing Non-integrin 1; HIV GP120 Binding Protein; SIGN-R1; SIGNR5
Antigen Type:
Recombinant protein
Gene Name: CD209
Gene ID: 30835
Primary Accession: Q9NNX6
Other Accession: 278694
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