CD22 polyclonal, anti-human, mouse

Background:
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through.

Synonyms: SIGLEC-2, SIGLEC2

Cellular Location: Cell membrane Single-pass type I membrane protein

Immunogen:
Recombinant protein of human CD22

Gene Symbol: CD22

Gene ID: 933

Swiss prot: P20273

Calculated MW: 95kDa

Recommended dilution:
WB 1:500-2000, IF 1:10-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.