CD22 Polyclonal Antibody

Background:
The B lymphocyte specific CD22 antigen, also designated B-lymphocyte cell adhesion molecule (BLCAM), sialic acid-binding Ig-like lectin 2 (Siglec-2) and Leu-14, is a type I integral membrane glycoprotein, structurally similar to other cell adhesion molecules (CAMs), which acts as a regulator of B cell signaling. CD22 is expressed as both a cytoplasmic and membrane protein during discrete stages of B cell lymphocyte differentiation. The cytoplasmic form of CD22, expressed early in B cell development, is a useful marker for acute lymphocytic leukemia. The membrane form of CD22 is expressed in mature B cells prior to their differentiation into plasma cells.

Research Area: Cancer, Immunology, Stem Cells

Synonyms:
B cell receptor CD22 precursor, B lymphocyte cell adhesion molecule, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL CAM, BL-CAM, BLCAM, CD 22, CD22, CD22 antigen, CD22 molecule, CD22 protein, CD22, Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, Sialic acid binding immunoglobulin like lectin 2, Sialic acid-binding Ig-like lectin 2, SIGLEC 2, Siglec-2, SIGLEC2, T cell surface antigen Leu 14, T-cell surface antigen Leu-14

Immunogen: Recombinant protein of human CD22

Swissprot: P20273
Gene Accession: BC109306

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7031/sc-7032/sc-7932