CD22 Polyclonal Antibody

Background:
CD22,also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule),is a 130-140 kDa,B-cell restricted,type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling,preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.

Research Area: Cancer, Immunology, Stem Cells

Synonyms:
B cell receptor CD22 precursor, B lymphocyte cell adhesion molecule, BL CAM, CD 22, CD22 antigen, CD22 molecule, Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, SIGLEC 2, T cell surface antigen Leu 14

Immunogen: Recombinant Human B-cell receptor CD22 protein

Swissprot: P20273
Gene ID: 933

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.