CD220 (clone 1A1G3), anti-

Background:
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Research Area: Others

Synonyms: INSR, HHF5

Immunogen: Purified recombinant fragment of human CD220 (AA: extra 413-624) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage