CD222 (Mannose 6 Phosphate Receptor(Cation independent)) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.

Description:
Rabbit IgG polyclonal antibody for Cation-independent mannose-6-phosphate receptor (IGF2R) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
300 kDa mannose 6 phosphate receptor antibody, 300 kDa mannose 6-phosphate receptor antibody, Cation independent mannose 6 phosphate receptor antibody, Cation-independent mannose-6-phosphate receptor antibody, CD222 antibody, CD222 antigen antibody, CI Man 6 P receptor antibody, CI Man-6-P receptor antibody, CI MPR antibody, CI-MPR antibody, CIMPR antibody, IGF 2 receptor antibody, IGF 2R antibody, IGF II receptor antibody, IGF-II receptor antibody, IGF2 receptor antibody, IGF2R antibody, Insulin like growth factor 2 receptor antibody, Insulin like growth factor II receptor antibody, Insulin-like growth factor 2 receptor antibody, Insulin-like growth factor II receptor antibody, M6P R antibody, M6P/IGF2 receptor antibody, M6P/IGF2R antibody, M6PR antibody, MPR 300 antibody, MPR300 antibody, MPRI antibody, MPRI_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Mannose 6 Phosphate Receptor(Cation independent)(2475-2491aa TKLVSFHDDSDEDLLHI), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human Mannose 6 Phosphate Receptor(Cation independent)(2475-2491aa TKLVSFHDDSDEDLLHI), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.